27 articles - From Friday Sep 16 2022 to Friday Sep 23 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: a meta-analysis of individual participant data. Maternal MMS was associated with a greater GWG % adequacy and total GWG at delivery compared to iron and folic acid only. This finding is consistent with previous results on birth outcomes and will inform policy development and local recommendation of switching routine prenatal iron and folic acid supplements to MMS. |
| Inflamm Bowel Dis |
Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis. Our results indicate that sample type variation is an important contributor to study variability that should be carefully considered during study design, and stool is likely superior to biopsy for CD studies due to its lower heterogeneity. |
| J Crohns Colitis |
Comparison of the risk of Crohn's disease postoperative recurrence between modified Rutgeerts score i2a and i2b categories: an individual patient data meta-analysis. In this individual patient data meta-analysis, no difference was observed between i2a and i2b subcategories with regards to clinical or surgical postoperative recurrence. As we wait for prospective trials, the same treatment strategy could be applied to al patients classified as i2 on the Rutgeerts score. |
Perianal Crohn's disease and the development of colorectal and anal cancer: A systematic review and meta-analysis. Half of patients with colorectal cancer and anal cancer were found to have perianal Crohn's. In patients with perianal involvement, there was a higher percentage of anal cancer compared with rectal cancer. These results support the theory that patients with perianal Crohn's are at increased risk for developing colorectal- and anal cancer. Studies, collecting more detailed data about patients and their cancers, are necessary to further specify the disease course. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
Association between serum 25-hydroxy vitamin D concentrations and mortality among individuals with metabolic dysfunction-associated fatty liver disease: a prospective cohort study. This study suggested a nonlinearly inverse association between serum 25(OH)D concentrations and all-cause mortality among patients with MAFLD/NAFLD, with a threshold effect at around 50.0 nmol/L of serum 25(OH)D. |
Greater Adherence to the 2019 Canada's Food Guide Recommendations On Healthy Food Choices Reduces the Risk of Cardiovascular Disease in Adults: a Prospective Analysis of UK Biobank Data. Compared with no change in the HEFI-2019 score, increasing the HEFI-2019 score of al participants to the 90th percentile of the score distribution (58.1 points) would hypothetically reduce the risk of CVD by 24% (relative risk, 0.76; 95%CI: 0.58, 0.94; absolute risk difference, -0.58%). These results suggest that greater adherence to the 2019 CFG recommendations on healthy food choices reduces the 11-year risk of CVD in middle-aged and older adults. |
Hydrogen Intake Relieves Alcohol Consumption and Hangover Symptoms in Healthy Adults: a Randomized and Placebo-Controlled Crossover Study. Likewise, the consumption of H2 was negatively (OR: 0.035; 95% CI: 0.007, 0.168; P < 0.001) while female sex was positively (OR: 28.838; 95% CI: 5.961, 139.506; P < 0.001) correlated with the severity of hangover symptoms. H2 decreases BrACs and relieves the symptoms of hangovers. |
Nutritionally Adequate and Environmentally Respectful Diets Are Possible for Different Diet Groups: an Optimized Study from the NutriNet-Santé Cohort. A low-meat diet could be considered as a target for the general population in the context of sustainable transitions, although al diets tested can be overall nutritionally adequate, except for 3-n fatty acids, when planned appropriately. NutriNet-Santé cohort is registered at: |
One-year longitudinal association between changes in dietary choline or betaine intake association with cardiometabolic variables in the PREDIMED-Plus trial. Increase in dietary choline or betaine intake were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they required further investigation. |
Overall Diet Quality and Proinflammatory Diet in Relation to Risk of Obstructive Sleep Apnea in Three Prospective US Cohorts. The association with AHEI was no longer statistically significant (comparable HR: 0.98; 95% CI: 0.91, 1.05; P-trend = 0.54), whereas the association with EDIP remained statistically significant (comparable HR: 1.31; 95% CI: 1.22, 1.41; P-trend < 0.001). A healthier diet, particularly the one with anti-inflammatory potential, was associated with lower OSA risk. |
The Impact of Almonds and Almond Processing On Gastrointestinal Physiology, Luminal Microbiology and Gastrointestinal Symptoms: a Randomized Controlled Trial and Mastication Study. Almond consumption has limited impact on gut microbiota composition but increases butyrate concentrations in adults, suggesting positive alterations to microbiota functionality. Almonds can be incorporated into the diet to increase fiber consumption without triggering gut symptoms. Clinical trial registry ClinicalTrials.gov identifier - NCT03581812. |
| Inflamm Bowel Dis |
Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant HLADQA1*05G>A Genotype. FCGRT VNTR and HLADQA1*05G>A are associated with lower maintenance-phase infliximab concentrations, particularly among patients who carry both variants. |
| J Crohns Colitis |
An extremes of phenotype approach confirms significant genetic heterogeneity in patients with ulcerative colitis. Our MRUC subgroup replicates multiple known UC risk variants in contrast to non-MRUC and demonstrates significant differences in effect sizes compared to those published. Non-MRUC cases demonstrate lower ORs similar to those published. Additional risk and prognostic loci may be identified by targeted recruitment of individuals with severe disease. |
Benefit of risk-stratified prophylactic treatment on clinical outcome in post-operative Crohn's disease. However, a large numerical albeit not statistical significant difference in 3 year clinical POR (28.6% vs 62.5%, p=0.11) in a subset of high-risk patients with =3 or more ECCO-defined risk factors was observed, indicating a cumulative effect of having multiple risk factors. Our observations favor step-up treatment guided by early endoscopic evaluation with prophylactic treatment reserved for carefully selected high-risk patients in order to avoid potential overtreatment of a significant number of patients. |
Disease Activity Patterns of Inflammatory Bowel Disease - A Danish Nationwide Cohort Study 1995-2018. We reported the distribution of disease patterns among IBD patients. Patients with quiescent CD, as well as UC patients with chronic continuous or increasing activity, were at increased risk of developing intestinal cancer. |
Epidemiology, treatment strategy, natural disease course and surgical outcomes of patients with ulcerative colitis in Western Hungary - a population-based study between 2007 and 2018, data from the Veszprem County cohort. The incidence of UC was high in Hungary, similar to high-incidence areas in Western Europe. Treatment strategies are in line with the biologic era. The probability of progressing into proximal disease, and the medium- and long-term colectomy rates were both lower compared data from Western European centers. |
Paediatric inflammatory bowel disease: a multi-stakeholder perspective to improve development of drugs for children and adolescents. Collaborative action points for al stakeholders are required to make progress and facilitate new drug development for children with inflammatory bowel disease. |
Patients with Inflammatory Bowel Disease Have Heterogeneous Treatment Preferences That Are Largely Determined by the Avoidance of Abdominal Pain and Side Effects [P-POWER IBD Study]. While avoiding abdominal pain, SEs, and serious infections had on average the highest treatment priority, preferences varied between patients. Treatment strategies should consider the trade-offs individuals are willing to make. |
Successful Dietary Therapy in Paediatric Crohn's Disease is Associated with Shifts in Bacterial Dysbiosis and Inflammatory Metabotype Towards Healthy Controls. Successful dietary therapy induced correction of both compositional and functional dysbiosis. However, 12 weeks of diet was not enough to achieve complete correction of dysbiosis. Our data suggests that composition and metabotype are important and change quickly during the early clinical response to dietary intervention. Correction of dysbiosis may therefore be an important future treatment goal for CD. |
The incidence and prevalence of paediatric- and adult-onset inflammatory bowel disease in Denmark during a 37-year period - a nationwide cohort study (1980-2017). For pCD and pUC, the prevalence was 35 (95% CI: 31 - 38) and 28 (95% CI: 26 - 32) per 100 000. The incidence of paediatric- and adult-onset IBD continues to increase and is among the highest in the world. |
Tofacitinib for the treatment of ulcerative colitis: an integrated summary of up to 7.8 years of safety data from the global clinical program. IRs [95% CIs] for al tofacitinib doses: deaths, 0.23 [0.09-0.46]; serious infections, 1.69 [1.26-2.21]; herpes zoster [non-serious and serious], 3.30 [2.67-4.04]; opportunistic infections, 1.03 [0.70-1.46]; malignancies [excluding nonmelanoma skin cancer (NMSC)], 0.84 [0.55-1.24]; NMSC, 0.73 [0.45-1.10]; MACE, 0.29 [0.13-0.55]; deep vein thrombosis, 0.03 [0.00-0.18]; pulmonary embolism, 0.19 [0.07-0.42]; gastrointestinal perforations, 0.10 [0.02-0.28]. AESI IRs were stable to 7.8 years and generally <2.0 in the Overall plus P3b/4 (2020) Cohort, with the exception of herpes zoster [a known risk of tofacitinib treatment]. |
| Liver Transpl |
Portopulmonary Hypertension Practice Patterns after Liver Transplantation. Our survey of PoPH providers showed that the majority of respondents favored serial integrated cardiopulmonary testing (including routine right heart catheterization) to guide adjustment of targeted therapy in PoPH after LT, and almost one fifth of respondents weaned therapy immediately after LT. Our study demonstrates heterogeneity in PoPH practice patterns after LT, highlights differences between current practice patterns and the most recent guidelines, emphasizes the need for additional research, and supports a team-based approach to standardize care for these high-risk patients and optimize post-LT outcomes. |
Practice Patterns of the Medical Evaluation of Living Liver Donors in the United States. At most centers, need for cardiovascular ischemic risk testing is based on age (73.6%) and the presence of one or more cardiac risk factors (68.0%). Defining areas of practice consensus and variation underscore the need for data generation in order to develop evidence-based guidance for the evaluation and risk assessment of living liver donors. |
Viability assessment and transplantation of fatty liver grafts using end-ischemic normothermic machine perfusion. Overall, NMP allowed successful transplantation of 57% of livers with moderate-to-severe MaS. Our findings suggest that prolonged observation (= |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| Liver Transpl |
Letters to the editors and authors’ replies